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| Date | Location | Result | |
| 05/04/2022 | Chicago, Ill. | Univ. of Chicago 19, Ill. Wesleyan 1 | Box score |
| 04/30/2022 | Bloomington, Ill. | Carthage 18, Ill. Wesleyan 12 | Box score |
| 04/23/2022 | Chicago, Ill. | Univ. of Chicago 24, Ill. Wesleyan 6 | Box score |
| 04/20/2022 | Elmhurst, Ill. | Ill. Wesleyan 25, Elmhurst 1 | Box score |
| 04/16/2022 | Bloomington, Ill. | Ill. Wesleyan 17, North Central 7 | Box score |
| 04/10/2022 | Chicago, Ill. | Christopher Newport 20, Ill. Wesleyan 1 | Box score |
| 04/09/2022 | Bloomington, Ill. | Ill. Wesleyan 20, Augustana 5 | Box score |
| 04/02/2022 | Bloomington, Ill. | CARROLL 11, Ill. Wesleyan 10 | Box score |
| 03/27/2022 | La Crosse, Wis. | UW-River Falls 16, Ill. Wesleyan 8 | Box score |
| 03/26/2022 | La Crosse, Wis. | Ill. Wesleyan 12, UW-La Crosse 11 | Box score |
| 03/21/2022 | Bloomington, Ill. | George Fox 19, Ill. Wesleyan 3 | Box score |
| 03/16/2022 | Los Angeles, CA | Occidental 24, Ill. Wesleyan 16 | Box score |
| 03/14/2022 | Claremont, Calif. | Claremont-M-S 22, Ill. Wesleyan 1 | Box score |
| 03/10/2022 | Bloomington, Ill. | Aurora 10, Ill. Wesleyan 5 | Box score |
| 03/06/2022 | Bloomington, Ill. | Ill. Wesleyan 16, Concordia-Chicago 7 | Box score |
| 03/05/2022 | Bloomington, Ill. | Capital 18, Ill. Wesleyan 3 | Box score |
| 02/27/2022 | Memphis, TN | Rhodes 18, Ill. Wesleyan 5 | Box score |
| 02/26/2022 | Memphis, Tenn. | Colorado Col. 21, Ill. Wesleyan 7 | Box score |