|
| Date | Location | Result | |
| 03/12/22 | Bloomington, Ill. (Shirk Center) | Wabash 81, Ill. Wesleyan 75 | Box score |
| 03/11/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 77, Wheaton (IL) 73 | Box score |
| 03/05/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 65, Wis.-La Crosse 56 | Box score |
| 03/04/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 73, Franklin 55 | Box score |
| 02/25/22 | Bloomington, Ill. (Shirk Center) | North Central (IL) 81, Ill. Wesleyan 74 | Box score |
| 02/19/22 | Rock Island, Ill. (Carver Center) | Ill. Wesleyan 70, Augustana (IL) 64 | Box score |
| 02/16/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 78, North Central (IL) 65 | Box score |
| 02/12/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 79, Wheaton (IL) 71 | Box score |
| 02/09/22 | Decatur, Ill. (Griswold Center) | Ill. Wesleyan 51, Millikin 49 | Box score |
| 02/07/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 73, North Park 49 | Box score |
| 02/05/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 66, Carthage 57 | Box score |
| 01/29/22 | Bloomington, Ill. (Shirk Center) | Concordia Chicago 81, Ill. Wesleyan 75 (OT) | Box score |
| 01/26/22 | Elmhurst, Ill. (R.A. Faganel Hall) | Elmhurst 74, Ill. Wesleyan 66 | Box score |
| 01/24/22 | Kenosha, Wis. (Tarble Arena) | Ill. Wesleyan 89, Carthage 72 | Box score |
| 01/22/22 | Waukesha, Wis. (Van Male Fieldhouse) | Ill. Wesleyan 72, Carroll (WI) 54 | Box score |
| 01/19/22 | Chicago, Ill. (NPU Gymnasium) | Ill. Wesleyan 63, North Park 58 | Box score |
| 01/17/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 80, Elmhurst 76 | Box score |
| 01/15/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 83, Augustana (IL) 78 | Box score |
| 01/12/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 78, Millikin 67 | Box score |
| 12/30/21 | New York, NY | Ill. Wesleyan 73, Yeshiva 59 | Box score |
| 12/19/21 | St. Louis, MO | WashU 71, Ill. Wesleyan 61 | Box score |
| 12/15/21 | Naperville, IL | Ill. Wesleyan 73, North Central (IL) 48 | Box score |
| 12/11/21 | Wheaton, IL | Wheaton (IL) 67, Ill. Wesleyan 62 | Box score |
| 12/04/21 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 63, Carroll (WI) 44 | Box score |
| 12/01/21 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 83, Chicago 50 | Box score |
| 11/20/21 | Van Noord Arena (Grand Rapids, Mich.) | Ill. Wesleyan 81, Calvin 72 | Box score |
| 11/19/21 | Alma, Mich. (Art Smith Arena) | Ill. Wesleyan 91, Alma 74 | Box score |
| 11/13/21 | Shirk Center (Bloomington, Ill.) | Ill. Wesleyan 65, Wis.-Oshkosh 63 | Box score |
| 11/12/21 | Shirk Center (Bloomington, Ill.) | Ill. Wesleyan 87, Hope 74 | Box score |
| 11/07/21 | Shirk Center (Bloomington, Ill.) | Ill. Wesleyan 81, Lake Forest 61 | Box score |