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| Date | Location | Result | |
| 03/05/22 | Whitewater, Wis. (Kachel Gymnasium) | Wis.-Whitewater 72, Ill. Wesleyan 54 | Box score |
| 03/04/22 | Whitewater, Wis. (Kachel Gymnasium) | Ill. Wesleyan 56, DePauw 55 | Box score |
| 02/26/22 | Decatur, Ill. (Griswold Center) | Ill. Wesleyan 80, Millikin 73 | Box score |
| 02/25/22 | Decatur, Ill. (Griswold Center) | Ill. Wesleyan 65, Carroll (WI) 60 | Box score |
| 02/19/22 | Rock Island, Ill. (Carver Center) | Ill. Wesleyan 65, Augustana (IL) 62 | Box score |
| 02/16/22 | Naperville, Ill. (Gregory Arena) | Ill. Wesleyan 65, North Central (IL) 63 | Box score |
| 02/12/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 81, Wheaton (IL) 54 | Box score |
| 02/09/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 81, North Park 60 | Box score |
| 02/07/22 | Decatur, Ill. (Griswold Center) | Millikin 67, Ill. Wesleyan 56 | Box score |
| 02/05/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 58, Carthage 52 | Box score |
| 01/26/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 85, Elmhurst 60 | Box score |
| 01/24/22 | Chicago, Ill. | Ill. Wesleyan 68, North Park 49 | Box score |
| 01/22/22 | Waukesha, Wis. (Van Male Fieldhouse) | Carroll (WI) 70, Ill. Wesleyan 48 | Box score |
| 01/19/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 73, Millikin 51 | Box score |
| 01/15/22 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 81, Augustana (IL) 48 | Box score |
| 01/10/22 | Elmhurst, Ill. | Ill. Wesleyan 85, Elmhurst 59 | Box score |
| 01/08/22 | Kenosha, Wis. (Tarble Arena) | Ill. Wesleyan 79, Carthage 60 | Box score |
| 12/31/21 | Forest Grove, Ore. | Pacific 71, Illinois Wesleyan 65 | Box score |
| 12/30/21 | Newberg, Ore. | Ill. Wesleyan 65, George Fox 61 | Box score |
| 12/18/21 | Bloomington, Ill. (Shirk Center) | Chicago 63, Ill. Wesleyan 62 | Box score |
| 12/15/21 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 74, North Central (IL) 59 | Box score |
| 12/11/21 | Wheaton, Ill. (King Arena) | Ill. Wesleyan 81, Wheaton (IL) 62 | Box score |
| 12/04/21 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 75, Carroll (WI) 62 | Box score |
| 12/01/21 | Bloomington, Ill. (Shirk Center) | Ill. Wesleyan 91, Eureka 41 | Box score |
| 11/28/21 | Bloomington, Ill. (Shirk Center) | WashU 83, Ill. Wesleyan 72 | Box score |
| 11/27/21 | Bloomington, Ill. (Shirk Center) | Rose-Hulman 69, Ill. Wesleyan 64 (OT) | Box score |
| 11/20/21 | Bloomington, Ill. (Shirk Center) | Wis.-Whitewater 75, Ill. Wesleyan 43 | Box score |
| 11/13/21 | Bexley, Ohio | Ill. Wesleyan 75, Capital 67 | Box score |
| 11/12/21 | Springfield, Ohio | Wittenberg 68, Ill. Wesleyan 59 | Box score |